Front page
Handbook information
Part 1: Cochrane reviews
Part 2: General methods for Cochrane reviews
Part 3: Special topics
13 Including non-randomized studies
14 Adverse effects
15 Incorporating economics evidence
16 Special topics in statistics
16.1 Missing data
16.2 Intention-to-treat issues
16.3 Cluster-randomized trials
16.4 Cross-over trials
16.4.1 Introduction
16.4.2 Assessing suitability of cross-over trials
16.4.3 Assessing risk of bias in cross-over trials
16.4.4 Methods of analysis for cross-over trials
16.4.5 Methods for incorporating cross-over trials into a meta-analysis
16.4.6 Approximate analyses of cross-over trials for a meta-analysis
16.4.7 Issues in the incorporation of cross-over trials
16.5 Studies with more than two intervention groups
16.6 Indirect comparisons and multiple-treatments meta-analysis
16.7 Multiplicity and the play of chance
16.8 Bayesian and hierarchical approaches to meta-analysis
16.9 Rare events (including zero frequencies)
16.10 Chapter information
16.11 References
17 Patient-reported outcomes
18 Reviews of individual patient data
19 Prospective meta-analysis
20 Qualitative research and Cochrane reviews
21 Reviews in public health and health promotion
22 Overviews of reviews
Additional material
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