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What are the experimental and control (comparator) interventions of interest
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Does the intervention have variations (e.g. dosage/intensity, mode of delivery, personnel who deliver it, frequency of delivery, duration of delivery, timing of delivery)?
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Are all variations to be included (for example is there a critical dose below which the intervention may not be clinically appropriate)?
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How will trials including only part of the intervention be handled?
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How will trials including the intervention of interest combined with another intervention (co-intervention) be handled?
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