How is the disease/condition defined?

What are the most important characteristics that describe these people (participants)?

Are there any relevant demographic factors (e.g. age, sex, ethnicity)?

What is the setting (e.g. hospital, community etc)?

Who should make the diagnosis?

Are there other types of people who should be excluded from the review (because they are likely to react to the intervention in a different way)?

How will studies involving only a subset of relevant participants be handled?