Chapter 16:  Special topics in statistics

Editors: Julian PT Higgins, Jonathan J Deeks and Douglas G Altman on behalf of the Cochrane Statistical Methods Group


Key points


16.1 Missing data

16.2 Intention-to-treat issues

16.3 Cluster-randomized trials

16.4 Cross-over trials

16.5 Studies with more than two intervention groups

16.6 Indirect comparisons and multiple-treatments meta-analysis

16.7 Multiplicity and the play of chance

16.8 Bayesian and hierarchical approaches to meta-analysis

16.9 Rare events (including zero frequencies)

16.10 Chapter information

16.11 References