Item

Yes

No

Not clear

Not appropriate

Study design

1.

The research question is stated.

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2.

The economic importance of the research question is stated.

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3.

The viewpoint(s) of the analysis are clearly stated and justified.

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4.

The rationale for choosing alternative programmes or interventions compared is stated.

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5.

The alternatives being compared are clearly described.

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6.

The form of economic evaluation used is stated.

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7.

The choice of form of economic evaluation is justified in relation to the questions addressed.

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Data collection

8.

The source(s) of effectiveness estimates used are stated.

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9.

Details of the design and results of effectiveness study are given (if based on a single study).

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10.

Details of the methods of synthesis or meta-analysis of estimates are given (if based on a synthesis of a number of effectiveness studies).

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11.

The primary outcome measure(s) for the economic evaluation are clearly stated.

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12.

Methods to value benefits are stated.

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13.

Details of the subjects from whom valuations were obtained were given.

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14.

Productivity changes (if included) are reported separately.

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15.

The relevance of productivity changes to the study question is discussed.

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16.

Quantities of resource use are reported separately from their unit costs.

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17.

Methods for the estimation of quantities and unit costs are described.

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18.

Currency and price data are recorded.

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19.

Details of currency of price adjustments for inflation or currency conversion are given.

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20.

Details of any model used are given.

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21.

The choice of model used and the key parameters on which it is based are justified.

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Analysis and interpretation of results

22.

Time horizon of costs and benefits is stated.

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23.

The discount rate(s) is stated.

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24.

The choice of discount rate(s) is justified.

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25.

An explanation is given if costs and benefits are not discounted.

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26.

Details of statistical tests and confidence intervals are given for stochastic data.

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27.

The approach to sensitivity analysis is given.

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28.

The choice of variables for sensitivity analysis is justified.

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29.

The ranges over which the variables are varied are justified.

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30.

Relevant alternatives are compared.

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31.

Incremental analysis is reported.

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32.

Major outcomes are presented in a disaggregated as well as aggregated form.

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33.

The answer to the study question is given.

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34.

Conclusions follow from the data reported.

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35.

Conclusions are accompanied by the appropriate caveats.

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