Table 10.2.a: Publication status of five cohorts of research projects approved by ethics committees or institutional review boards which had been completed and analysed at the time of follow-up.  (Adapted from Hopewell et al. (Hopewell 2008).)

 

Johns Hopkins University, Baltimore

National Institutes of Health, U.S.A.

Royal Prince Alfred Hospital, Sydney

National Agency for Medicine, Finland

National Institutes of Health, U.S.A., Multi-centre trials in HIV/AIDS

Reference

Dickersin 1992

Dickersin 1993

Stern 1997

Bardy 1998

Ioannidis 1998

Period of approval

1980

1979

1979-88

1987

1986-1996

Year of follow-up

1988

1988

1992

1995

1996

Number approved

168

198

130

188

66

Published

136 (81%)

184 (93%)

73 (56%)

68 (36%)

36 (54%)

    Positive*

84/96 (87%)

121/124 (98%)

55/76 (72%)

52/111 (47%)

20/27 (75%)

    Negative*

52/72 (72%)

63/74 (85%)

3/15 (20%)

5/44 (11%)

16/39 (41%)

Inconclusive/null (if assessed separately)

Not assessed

Not assessed

15/39 (38%)

11/33 (33%)

Not assessed

*Definitions differed by study.